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Serrazimes® is a proteolytic blend composed of enzymes derived from the edible fungi, Aspergillus oryzae and Aspergillus melleus.
- 20,000 Units of Activity
- Системски протеолитички ензими
<table class=”dcf-table dcf-table-responsive dcf-table-bordered dcf-table-striped dcf-w-100%”>
<th scope=”col”>Serving Size:</th>
<th scope=”col”>1 vcaps</th>
<th scope=”row”>Servings Per Container:</th>
<td data-label=”1 softgel”>90</td>
<th scope=”row”> * Daily Value not established.</th>
<td data-label=”1 softgel”>Amount per Serving</td>
<th scope=”row”>Serrazimes® (20,000 Serratiopeptidase Units)</th>
<td data-label=”1 softgel”>33 mg*</td>
<strong>Other ingredients:</strong> Rice Bran, Cellulose Powder and Cellulose (capsule).
Not manufactured with wheat, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Natural color variation may occur in this product.
Take 1 capsule 1 to 2 times daily between meals. Make sure to take on an empty stomach.
For adults only. Consult physician if pregnant/nursing, taking medication (especially blood thinning medications), or have a medical condition.
Keep out of reach of children. Do Not Eat Freshness Packet. Keep in Bottle. Store in a cool, dry place after opening.
Serrapeptidase is a protease initially isolated from Serratia marcescens, a potentially pathogenic bacteria,found in the gut of the Japanese silkworm. Recognized as a pharmaceutical agent and sold under the names Danzen and Aniflazyme, Serrapeptidase has wide clinical use in Asia and Europe for the treatment of assorted inflammatory disorders (Rothschild, 1991). In recent years, recognition of the efficacy of this product has lead to growing interest in the US dietary supplement market. Despite international regulations, the product’s efficacy and availability over the internet has fueled its popularity in the US dietary supplement industry where it is used for anti-inflammatory support, cardiovascular support, respiratory support, and as an adjunct to antibiotic therapy. Recognizing the potential for a “Serrapeptidase-type” enzyme in the U.S. dietary supplement market, National Enzyme Company set fourth to develop a protease system that has the same in vitro activity as Serrapeptidase, but that is from a source organism(s) that has a long history of safe use in dietary supplements. Serrazimes™ is the product of this search.
Serrapeptidase has been used in Europe and Asia to treat heart disease, inflammatory diseases, and bacterial infections for over 25 years. The proteolytic activities of Serrapeptidase explain these applications. Serrazimes™ exhibits these same proteolytic activities in vitro, demonstrating that Serrazimes™ is an excellent alternative for Serrapeptidase in supplements intended to provide cardiovascular, antiinflammatory, respiratory, or immune support.
Since the 1960’s plant and microbial proteases have been studied for their role in the treatment of inflammation and inflammatory disorders. In both animal and human trials, proteolytic enzymes, from a variety of sources, have repeatedly been shown to significantly reduce inflammation resulting from sickness or injury. Early research on the anti-inflammatory actions of proteases pointed entirely to their antithrombic and fibrinolytic aspects to explain this phenomenon. However, studies by Parmely and others indicate that, in addition to degrading fibrin, microbial proteases may actually inactivate pro-inflammatory cytokines to prevent or attenuate inflammatory cascades.
Evidence suggests this may be accomplished through hydrolysis of tumor necrosis factor alpha (TNFα) and/or interferon gamma (IFNγ). Numerous human trials have shown Serrapeptidase to be highly effective for treating the inflammation resulting from carpal tunnel syndrome, surgery/injury, and breast engorgement. Serrazimes™ shows in vitro activity similar to Serrapeptidase, but uses a protease system from Aspergillus melleus and Aspergillus oryzae. Like Serrapeptidase, protease from Aspergillus melleus has been shown both in vitro and in vivo to significantly inhibit inflammatory responses. However, in a head to head in vivo trial between protease from Aspergillus melleus and Serrapeptidase, protease from Aspergillus melleus not only showed better anti-inflammatory results than Serrapeptidase, but it also showed fewer side effects. For these reasons, it is clear that Serrazimes™ is not only an adequate substitution for Serrapeptidase in anti-inflammatory products, it may even be the better choice.
Side Effects, Contraindications, and Drug Interactions
Systemically used proteases are known to have antithrombic properties. Persons who suffer from clotting disorders or who are on antithrombic medications, such as warfarin, coumadin, or aspirin therapy may experience increased clotting times when using systemic proteases. Such persons should consult a physician prior to taking systemic doses of any protease, including Serrazimes™. Due to its effects on vascular permeability, the absorption and tissue distribution of antibiotics may be increased when administered concomitantly with Serrazimes™. Persons on antibiotics should consult their physicians prior to taking Serrazimes™.